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Inheritance Pattern of Sickle cell anaemia
Sickle cell anaemia is an inherited disease. Two genes for sickle cell haemoglobin must be inherited from parents to have the disease. The genes involved in sickle cell disease control the production of a protein in red blood cells called haemoglobin. The haemoglobin binds to oxygen in the lungs and releases it to the peripheral tissues such as the liver and muscles. Most people have two normal genes for haemoglobin. Some people carry one normal gene and one gene for sickle cell haemoglobin. Below, the figure represents the anaemic state of haemoglobin genes inherited from parents with sickle cell trait and character of haemoglobin C. As indicated above, the couple has four possibilities for the child to have the genes for haemoglobin and sickle cell haemoglobin. C. The child would have a Haemoglobin SC disease. The Haemoglobin SC disease is usually milder than sickle cell disease. Unfortunately, some patients have a clinical course indistinguishable from sickle cell anaemia.


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